Title :
In vitro Degradation Behavior of Photopolymerized PEG Hydrogels as Tissue Engineering Scaffold
Author :
Xin, Antonio X. ; Gaydos, Celeste ; Mao, Jeremy J.
Author_Institution :
Dept. of Dental Med. & Biomed. Eng., Columbia Univ., New York, NY
fDate :
Aug. 30 2006-Sept. 3 2006
Abstract :
PEGDA was photopolymerized to form hydrogels under different UV light irradiation times. In order to investigate the degradation rate in vitro, the various PEGDA hydrogels were incubated in PBS solution at 37degC in shaking water bath system. The physical-chemical properties such as pH values, dimension, mass and volume change, compressive strength and Young´s modulus were measured. MALDI-MS and SEM were employed to evaluate the PBS solutions and corroded hydrogels after a designed period of time till 8 weeks. The results indicate that the PEGDA formed hydrogels can be tailored with prompted properties specifically for various cell-based tissue engineering needs
Keywords :
Young´s modulus; biodegradable materials; biomedical materials; cellular biophysics; compressive strength; polymer gels; polymerisation; scanning electron microscopy; time of flight mass spectroscopy; tissue engineering; ultraviolet radiation effects; 37 C; SEM; UV light irradiation; Young´s modulus; cell-based tissue engineering; compressive strength; in vitro degradation behavior; matrix-assisted laser desorption-ionization time-of-flight mass spectrometry; pH values; photopolymerization; physical-chemical properties; poly (ethylene glycol) diacrylate hydrogel; shaking water bath system; tissue engineering scaffold; Analysis of variance; Cities and towns; Degradation; Dentistry; In vitro; Statistical analysis; Surface morphology; Testing; Tissue engineering; USA Councils;
Conference_Titel :
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location :
New York, NY
Print_ISBN :
1-4244-0032-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2006.260811
