Circadian phase control using observer-based back-stepping design

Author

That, Long Ton ; Ding, Zhengtao

Author_Institution

Sch. of Electr. & Electron. Eng., Control Syst. Centre, Univ. of Manchester, Manchester, UK

fYear

2011

fDate

19-21 Dec. 2011

Firstpage

824

Lastpage

829

Abstract

Circadian rhythms exist in most of living species, and control their daily biological activities. Disruption of these rhythms can cause circadian disorders or phase shifts. This paper deals with phase recovery of circadian rhythms. The phase restoration is carried out by synchronization of estimated trajectories of unknown state variables of a controlled system with trajectories of a reference system via back-stepping. The unknown state variables are estimated by using recently developed one-sided Lipschitz observer. Both reference and controlled systems are based on a 3rd order model of Neurospora circadian rhythms. Several simulation studies are carried out to verify the operation of proposed synchronization scheme with results shown in this paper.

Keywords

biocontrol; circadian rhythms; estimation theory; observers; phase control; synchronisation; trajectory control; 3rd order model; Neurospora circadian rhythms; biological activity; circadian disorders; circadian phase control; controlled systems; living species; observer-based back-stepping design; one-sided Lipschitz observer; phase recovery; phase restoration; phase shifts; reference system; synchronization scheme; trajectory estimation; Circadian rhythm; Mathematical model; Observers; Proteins; Synchronization; Trajectory;

fLanguage

English

Publisher

ieee

Conference_Titel

Control and Automation (ICCA), 2011 9th IEEE International Conference on

Conference_Location

Santiago

ISSN

1948-3449

Print_ISBN

978-1-4577-1475-7

Type

conf

DOI

10.1109/ICCA.2011.6138088

Filename

6138088