Title :
Nanocomposite hydrogels : A novel wound dressings
Author :
Zhou, Y.M. ; Mizuno, T. ; Takehisa, T. ; Haraguchi, K. ; Taenaka, Y.
Author_Institution :
Kawamura Inst. of Chem. Res., Chiba, Japan
Abstract :
This A novel class of nanocomposite hydrogels (NC gels) with a unique organic / inorganic network structure was synthesized by in-situ free-radical polymerization of N-isopropylacrylamide (NIPA) or N,N-dimethylacrylamide (DMAA) in the presence of inorganic clay (hectorite). Here, we investigated the effect of NC gel films on the healing of artificial wounds in adult goats. Our results indicate that NC gel films improved the healing rate of artificial wounds in adult goats. We also obtained a good clinical outcome in the treatment of a poorly healing pressure leg ulcer wound of bovine. Thus, NC gel should be a candidate for wound care.
Keywords :
biomedical materials; clay; free radical reactions; hydrogels; nanobiotechnology; nanocomposites; nanofabrication; organic-inorganic hybrid materials; polymerisation; wounds; N,N-dimethylacrylamide; N-isopropylacrylamide; NC gel films; adult goats; artificial wound healing; bovine; hydrogels; in-situ free-radical polymerization; nanocomposite; organic-inorganic network structure; pressure leg ulcer wound; wound dressings; Bovine; Films; Leg; Mechanical factors; Wounds; component; formatting; insert; style; styling;
Conference_Titel :
Biomedical Engineering and Informatics (BMEI), 2010 3rd International Conference on
Conference_Location :
Yantai
Print_ISBN :
978-1-4244-6495-1
DOI :
10.1109/BMEI.2010.5639558