A new injectable tissue engineered scaffold for regenerative medicine

Author

Hosseinkhani, Hossein ; Hosseinkhani, Mohsen ; Kobayashi, Hisatoshi

Author_Institution

Int. Center for Young Scientists, Nat. Inst. for Mater. Sci., Tsukuba

fYear

2006

fDate

9-12 May 2006

Firstpage

10

Lastpage

11

Abstract

The failure of the application of tissue engineering in clinical trials is questionable. Tissue-engineering scaffolds used in tissue regeneration have micron structures that fail to be analogous to native extracellular matrix (ECM) in terms of both chemical composition and physical structure as a suitable surface structure for cell attachment, proliferation, and differentiation. In this study we designed an artificial ECM in order to mimic the nano-structured topography created by ECM components of native tissue. Selective differentiation of cardiomyocytes cells by self assembly of peptide-amphiphile nanofibers was studied for in vivo cardiac infarction therapy

Keywords

biomedical materials; cardiovascular system; cellular biophysics; nanostructured materials; nanotechnology; self-assembly; surface structure; tissue engineering; artificial extracellular matrix; cardiomyocytes; cell attachment; cell differentiation; cell proliferation; chemical composition; in vivo cardiac infarction therapy; injectable tissue engineered scaffold; nano-structured topography; native extracellular matrix; peptide-amphiphile nanofibers; physical structure; regenerative medicine; self assembly; surface structure; tissue regeneration; Cardiology; Chemicals; Clinical trials; Electrochemical machining; Extracellular; In vivo; Regeneration engineering; Self-assembly; Surface structures; Tissue engineering; extracellular matrix; nanofibers; regeneration; scaffold; self-assembly;

fLanguage

English

Publisher

ieee

Conference_Titel

Microtechnologies in Medicine and Biology, 2006 International Conference on

Conference_Location

Okinawa

Print_ISBN

1-4244-0338-3

Electronic_ISBN

1-4244-0338-3

Type

conf

DOI

10.1109/MMB.2006.251477

Filename

4281294