CMOS Neurotransmitter Microarray: 96-Channel Integrated Potentiostat With On-Die Microsensors

Author

Nazari, Masoud Honarvar ; Mazhab-Jafari, H. ; Lian Leng ; Guenther, A. ; Genov, Roman

Author_Institution

Dept. of Electr. & Comput. Eng., Univ. of Toronto, Toronto, ON, Canada

Volume

7

Issue

3

fYear

2013

fDate

Jun-13

Firstpage

338

Lastpage

348

Abstract

A 8 × 12 array of integrated potentiostats for on-CMOS neurotransmitter imaging is presented. Each potentiostat channel measures bidirectional redox currents proportional to the concentration of a neurochemical. By combining the current-to-frequency and the single-slope analog-to-digital converter (ADC) architectures a total linear dynamic range of 95 dB is achieved. A 3.8 mm × 3.1 mm prototype fabricated in a 0.35 μm standard CMOS technology was integrated with flat and 3D on-die gold microelectrodes and an on-chip microfluidic network. It is experimentally validated in in-situ recording of neurotransmitter dopamine.

Keywords

CMOS logic circuits; analogue-digital conversion; bioMEMS; biochemistry; biomedical electrodes; biomedical electronics; biomedical measurement; brain; lab-on-a-chip; medical disorders; microelectrodes; microfluidics; microsensors; network-on-chip; neurophysiology; 3D on-die gold microelectrodes; 96-channel integrated potentiostat; ADC converter; CMOS neurotransmitter microarray; bidirectional redox currents; current-frequency converter; integrated potentiostat array; neurochemical concentration; neurotransmitter dopamine; on-CMOS neurotransmitter imaging; on-chip microfluidic network; on-die microsensors; single-slope analog-digital converter; CMOS integrated circuits; Capacitors; Computer architecture; Electrodes; Neurotransmitters; Noise; Transistors; Dopamine; gold microelectrode; microfludic network; neurochemical imaging; potentiostat; Action Potentials; Biosensing Techniques; Brain; Calibration; Dopamine; Electrochemistry; Equipment Design; Gold; Humans; Microarray Analysis; Microelectrodes; Microfluidic Analytical Techniques; Miniaturization; Neurotransmitter Agents; Oxidation-Reduction; Potentiometry; Semiconductors; Signal-To-Noise Ratio;

fLanguage

English

Journal_Title

Biomedical Circuits and Systems, IEEE Transactions on

Publisher

ieee

ISSN

1932-4545

Type

jour

DOI

10.1109/TBCAS.2012.2203597

Filename

6265342