Title :
Molecular nanoelectronics for label free DNA analysis
Author :
Lee, L.P. ; Oh, S. ; Choi, Y. ; Lee, J.S.
Author_Institution :
Dept. of Bioeng., California Univ., Berkeley, CA, USA
Abstract :
An ultrasensitive nanogap junction is developed for label-free biomolecular detection. The nanogap junction can minimize the effects of electrode polarization. Without any label, dielectric detection of DNA hybridization is accomplished: the 70% and 12% changes of capacitance after hybridization were accomplished at 100 Hz for 10 /spl mu/M and 10 fM concentrations of target DNA, respectively. The nanogap junction-based dielectric DNA detection method and the batch fabrication method of nanogap junctions might able to change the paradigm of functional genomics and proteomics.
Keywords :
DNA; biomolecular electronics; biosensors; capacitance; micromechanical devices; nanoelectronics; 100 Hz; DNA analysis; DNA hybridization; batch fabrication; bioMEMS; capacitance; dielectric detection; functional genomics; label-free biomolecular detection; molecular nanoelectronics; proteomics; ultrasensitive nanogap junction; Bioinformatics; Capacitance; DNA; Dielectrics; Electrodes; Fabrication; Genomics; Nanoelectronics; Polarization; Proteomics;
Conference_Titel :
Microprocesses and Nanotechnology Conference, 2002. Digest of Papers. Microprocesses and Nanotechnology 2002. 2002 International
Conference_Location :
Tokyo, Japan
Print_ISBN :
4-89114-031-3
DOI :
10.1109/IMNC.2002.1178655
