Title :
A semiconductor nanobridge biosensor for electrical detection of DNA hybridization
Author :
Parizi, K.B. ; Nishi, Y.
Author_Institution :
Electr. Eng. Dept., Stanford Univ., Stanford, CA
Abstract :
In this paper, the modeling, fabrication and optimization of the proposed nanobiosensor for detection of biomolecules such as DNA hybridization has been studied and different advantages and disadvantages of such a device are discussed. This paper outlines how the modulation of impedance in a novel silicon nanobridge (nanowire) biosensor can be used in characterizing biochemical species such as a antibodies/antigens or for detection of a particular DNA sequence hybridization. The array of biosensors fabricated from a SOI wafer with the thickness of 50 nm are studied and simulations are carried out using the TCAD simulator (MEDICI) softwares.
Keywords :
DNA; biochemistry; bioelectric phenomena; biosensors; electric impedance; elemental semiconductors; molecular biophysics; nanobiotechnology; nanowires; semiconductor device models; semiconductor quantum wires; silicon; silicon-on-insulator; technology CAD (electronics); DNA hybridization; MEDICI software; SOI wafer; Si; TCAD simulator; antibodies; antigens; electrical detection; impedance; nanobiosensor; optimization; semiconductor nanobridge biosensor; silicon nanobridge; silicon nanowire; size 50 nm; Biomedical optical imaging; Biosensors; Conference proceedings; Couplings; DNA; Fabrication; Phase detection; Semiconductor films; Silicon; Voltage;
Conference_Titel :
SOI Conference, 2008. SOI. IEEE International
Conference_Location :
New Paltz, NY
Print_ISBN :
978-1-4244-1954-8
Electronic_ISBN :
1078-621X
DOI :
10.1109/SOI.2008.4656307
