Computer-aided tissue engineering for bone regeneration

Author

Rainer, Alberto ; Mozetic, Pamela ; Giannitelli, Sara M. ; Accoto, Dino ; De Porcellinis, Stefano ; Guglielmelli, Eugenio ; Trombetta, Marcella

Author_Institution

Tissue Eng. Lab., Univ. Campus Bio-Medico di Roma, Rome, Italy

fYear

2012

fDate

24-27 June 2012

Firstpage

473

Lastpage

476

Abstract

Computer-aided tissue engineering comprises a set of methodologies for the fabrication of prosthetic implants by means of rapid prototyping technologies. The paper presents a technique for the preparation of bioactive implants intended to be used in combination with mesenchymal stem cells for the regeneration of bone tissue. The methodology uses additive manufacturing of scaffolds according to a topological optimization algorithm and combines it with chemical functionalization protocols to increase material bioactivity.

Keywords

bone; computer aided manufacturing; medical computing; optimisation; prosthetics; rapid prototyping (industrial); tissue engineering; topology; additive manufacturing; bioactive implants; bone regeneration; bone tissue; chemical functionalization protocols; computer-aided tissue engineering; material bioactivity; mesenchymal stem cells; prosthetic implants; rapid prototyping technologies; topological optimization algorithm; Bones; Computational modeling; Computer architecture; Fabrication; Materials; Stress; Tissue engineering;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Robotics and Biomechatronics (BioRob), 2012 4th IEEE RAS & EMBS International Conference on

Conference_Location

Rome

ISSN

2155-1774

Print_ISBN

978-1-4577-1199-2

Type

conf

DOI

10.1109/BioRob.2012.6290894

Filename

6290894