Title :
High Resolution Read-Out Circuit for DNA Label-Free Detection System
Author :
De Venuto, Daniela ; Ricco, Bruno
Author_Institution :
DEE Politecnico di Bari, Bari
Abstract :
This paper presents novel read-out electronic systems for a fast DNA label-less detection. The capacitive shift due to the hybridization effect is monitored by means of a charge sensitive amplifier and a differential stage. The systems provide an A/D conversion and an evaluation of the capacitive shift amount with a resolution of 11 bit. The read-out solutions demonstrate the ability to identify a 0.01% variation on the capacitive value of the sensor. The investigated techniques are suitable for monolithic systems or for a micro-fabricated array of sensors.
Keywords :
DNA; analogue-digital conversion; biochemistry; bioelectric phenomena; biosensors; capacitive sensors; readout electronics; A/D conversion; DNA label-free detection system; capacitive biosensor; charge sensitive amplifier; differential stage; high resolution read-out electronic systems; hybridization effect; micro-fabricated sensor array; monolithic systems; Biosensors; Capacitance; Capacitive sensors; Circuits; DNA; Electrodes; Gold; Monitoring; Sensor arrays; Sensor systems; DNA biosensor read-out. Charge sensitive front-end; differential read-out system.;
Conference_Titel :
Quality Electronic Design, 2008. ISQED 2008. 9th International Symposium on
Conference_Location :
San Jose, CA
Print_ISBN :
978-0-7695-3117-5
DOI :
10.1109/ISQED.2008.4479824
