Needle-free interstitial fluid acquisition using a lorentz-force actuated jet injector

Author

Chang, J.H. ; Hogan, N.C. ; Hunter, Ian W.

Author_Institution

Dept. of Mech. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA

fYear

2013

fDate

3-7 July 2013

Firstpage

3491

Lastpage

3494

Abstract

The feasibility of a new method of quickly acquiring interstitial fluid (ISF) samples using a Lorentz-force actuated needle-free jet injector is demonstrated on ex vivo porcine tissue. The jet injector is used to first inject a small volume of physiological saline to breach the skin, and the back-drivability of the actuator is utilized to create a vacuum in the ampoule and collect ISF. Injection and extraction parameters are tested and optimized for minimal acquired sample dilution and extracted volume consistency. Using this method, we are able to collect a sample that contains up to 3.5% ISF in 3.1 s.

Keywords

actuators; biological fluid dynamics; biological tissues; jets; needles; patient diagnosis; ISF collection; Lorentz-force actuated needle-free jet injector; actuator back-drivability; ampoule; ex vivo porcine tissue; extracted volume consistency; extraction parameter; injection parameter; interstitial fluid sample; minimal acquired sample dilution; needle-free interstitial fluid acquisition; physiological saline; time 3.1 s; Fluids; Pistons; Proteins; Skin; Sugar; Surface contamination; Tumors;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE

Conference_Location

Osaka

ISSN

1557-170X

Type

conf

DOI

10.1109/EMBC.2013.6610294

Filename

6610294