Open flow microperfusion-a novel approach for a hypoglycaemia warning device

Author

Schaupp, L. ; Ellmerer, M. ; Trajanoski, Z. ; Brunner, G.A. ; Pieber, T.R. ; Skrabal, F. ; Wach, P.

Author_Institution

Inst. of Biomed. Eng., Graz Univ. of Technol., Austria

Volume

1

fYear

1996

fDate

31 Oct-3 Nov 1996

Firstpage

79

Abstract

A system to monitor the subcutaneous tissue glucose concentration continuously and ex vivo with a portable device is presented. The method of open flow microperfusion was evaluated during hyperinsulinemic hypoglycaemic clamp experiments in 6 healthy volunteers. During these experiments good agreement (correlation coefficients 0.85-0.95, n=65-91) between blood glucoseand subcutaneous tissue glucose concentration could be observed. In conclusion, it could be shown that monitoring subcutaneous tissue glucose concentrations during hypoglycaemia is feasible with open flow microperfusion

Keywords

biosensors; patient monitoring; correlation coefficient; enzyme-based biosensor; healthy volunteers; hyperinsulinemic hypoglycaemic clamp experiments; medical instrumentation; open flow microperfusion; portable device; subcutaneous tissue glucose concentration monitoring system; Amperometric sensors; Blood; Calibration; Catheters; Clamps; Conductivity; Monitoring; Sensor arrays; Sugar; Temperature sensors;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE

Conference_Location

Amsterdam

Print_ISBN

0-7803-3811-1

Type

conf

DOI

10.1109/IEMBS.1996.656855

Filename

656855