Precision extruding deposition of composite polycaprolactone/hydroxyapatite scaffolds for bone tissue engineering

Author

Shor, L. ; Darling, A. ; Starly, B. ; Sun, W. ; Güçeri, S.

Author_Institution

Dept. of Mech. Eng. & Mech., Drexel Univ., Philadelphia, PA, USA

fYear

2005

fDate

2-3 April 2005

Firstpage

172

Lastpage

173

Abstract

Precision extruding deposition (PED) process was used to directly fabricate Polycaprolactone (PCL)/hydroxyapatite (HA) composite tissue scaffolds. HA powder was melt blended with PCL, a biodegradable polymer. Scaffolds with a controlled pore size of 400 μm and a 64% porosity were fabricated. The scaffold morphology and the mechanical properties were evaluated using SEM and mechanical testing. Preliminary biological study was conducted to investigate the cellular responses of the composite scaffolds. Results and characterizations demonstrate the viability of the PED process as well as the good mechanical property, structural integrity, controlled pore size, pore interconnectivity, and the biological compatibility of the fabricated PCL/HA scaffolds.

Keywords

biomedical materials; bone; cellular biophysics; composite materials; mechanical testing; polymers; porosity; scanning electron microscopy; tissue engineering; 400 micron; SEM; biodegradable polymer; biological compatibility; bone tissue engineering; composite polycaprolactone-hydroxyapatite scaffolds; controlled pore size; mechanical property; mechanical testing; melt blending; polycaprolactone; pore interconnectivity; precision extruding deposition; scaffold morphology; structural integrity; Biodegradable materials; Biological control systems; Bone tissue; Mechanical factors; Morphology; Polymers; Powders; Size control; Testing; Tissue engineering;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2005. Proceedings of the IEEE 31st Annual Northeast

Print_ISBN

0-7803-9105-5

Electronic_ISBN

0-7803-9106-3

Type

conf

DOI

10.1109/NEBC.2005.1431978

Filename

1431978