Design of molecular-based network robots-Toward the environmental control

Toward the intelligent control of internal and external environments, we present an idea of the sequence design for the network formation of DNA-based nanorobots. We already developed a DNA nanomachine that has the potential ability of producing a functional molecule called “aptamer” when bacterial two-component signal transduction systems are detected. Here we have succeeded in demonstrating the network formation based on the sticky-end programming of DNA modules. By combining the aptamer transcription function with the network formation ability, we can implement various missions in DNA nanomacines. The network design is essential to keep the appropriate density, configurations and functions to carry out target missions. We expect that the network of DNA nanorobots make a contribution to realize the effective regulation of microorganisms to promote environmental preservation and health maintenance.