On modeling electric fields for microscale cell manipulation

Author

Avdeev, Ilya V. ; Lovell, Michael R.

Author_Institution

Univ. of Wisconsin-Milwaukee, Milwaukee, WI, USA

fYear

2009

fDate

4-7 Nov. 2009

Firstpage

1

Lastpage

4

Abstract

Strongly-coupled finite element analysis is applied to modeling micromachined devices designed for biological cell manipulation. Nonuniform, fringing three-dimensional electric fields in heterogeneous media are accurately represented by finite element models. Cell manipulation by dielectrophoresis and direct contact and is discussed in detail. Two design cases are studied using the developed finite element methodology: a DEP cell sorter and a micro stage device for cell stretching. Results of the simulation agree with the experimental observations reported in the literature.

Keywords

bioMEMS; bioelectric phenomena; biological techniques; biomechanics; cellular biophysics; electric field effects; electrophoresis; electrostatics; finite element analysis; micromachining; DEP cell sorter; biological cell manipulation; cell stretching; dielectrophoresis; electric field modeling; heterogeneous media; micromachined device modeling; microscale cell manipulation; microstage device; nonuniform fringing 3D electric fields; strongly-coupled finite element analysis; Biological cells; Biological system modeling; Cells (biology); Dielectrophoresis; Electrostatics; Finite element methods; Micromechanical devices; Nonuniform electric fields; Polarization; Transducers; cell manipulation; dielectrophoresis; finite element method;

fLanguage

English

Publisher

ieee

Conference_Titel

Information Technology and Applications in Biomedicine, 2009. ITAB 2009. 9th International Conference on

Conference_Location

Larnaca

Print_ISBN

978-1-4244-5379-5

Electronic_ISBN

978-1-4244-5379-5

Type

conf

DOI

10.1109/ITAB.2009.5394383

Filename

5394383