Title :
Microchannel plate detectors for 14C autoradiography
Author :
Lees, J.E. ; Fraser, G.W. ; Carthew, P.
Author_Institution :
Dept. of Phys. & Astron., Leicester Univ., UK
Abstract :
The authors describe a new type of detector for digital autoradiography which combines high sensitivity, useful detecting area (93×93 mm) and good spatial resolution (<100 μm). This instrument is suitable, inter alia, for imaging beta-emitting whole body thin tissue slices. Measured detector sensitivity and linearity derived from images of a 14C standard are presented. The authors also describe results from (i) a 14C labelled rat whole body slice showing selective radiopharmaceutical uptake in clearly identifiable organs and (ii) 14C-Tamoxifen doped semi-thin tissue sections of rat womb and liver
Keywords :
biological techniques; carbon; image sensors; liver; radioisotope imaging; 14C autoradiography; 14C-Tamoxifen doped semithin tissue sections; C; beta-emitting whole body thin tissue slices; biological research technique; clearly identifiable organs; microchannel plate detectors; rat liver; rat womb; selective radiopharmaceutical uptake; spatial resolution; Astronomy; Extraterrestrial measurements; Gamma ray detection; Gamma ray detectors; High-resolution imaging; Instruments; Microchannel; Silicon; Spatial resolution; X-ray imaging;
Conference_Titel :
Nuclear Science Symposium, 1997. IEEE
Conference_Location :
Albuquerque, NM
Print_ISBN :
0-7803-4258-5
DOI :
10.1109/NSSMIC.1997.670626
