Penetration of high intensity focused ultrasound ex vivo and in vivo rabbit brain using MR imaging

Author

Hadjisavvas, Venediktos ; Damianou, Christakis ; Ioannides, Kleanthis ; Mylonas, Nicos ; Couppis, Andreas ; Kyriacou, Panayiotis A. ; Iosif, Dimitris ; HadjiCharalambous, Theodoros ; Parea, Gavriella

fYear

2009

fDate

4-7 Nov. 2009

Firstpage

1

Lastpage

4

Abstract

In this paper magnetic resonance imaging (MRI) is investigated for monitoring the penetration of high intensity focused ultrasound (HIFU) ex vivo and in vivo rabbit brain. A single element spherically focused transducer of 5 cm diameter, focusing at 10 cm and operating at 2 MHz was used. A prototype MRI- compatible positioning device is described. MRI images were taken using fast spin echo (FSE). The length of the lesions in vivo rabbit brain was much higher than the length ex vivo, proving that the penetration in the ex vivo brain is limited by reflection due to trapped bubbles in the blood vessels.

Keywords

biomedical MRI; biomedical ultrasonics; blood vessels; brain; MR imaging; blood vessels; bubbles; distance 10 cm; fast spin echo; frequency 2 MHz; high intensity focused ultrasound; lesions; magnetic resonance imaging; rabbit brain; size 5 cm; Focusing; In vivo; Lesions; Magnetic resonance imaging; Monitoring; Prototypes; Rabbits; Reflection; Ultrasonic imaging; Ultrasonic transducers; MRI; Ultrasound; lesion;

fLanguage

English

Publisher

ieee

Conference_Titel

Information Technology and Applications in Biomedicine, 2009. ITAB 2009. 9th International Conference on

Conference_Location

Larnaca

Print_ISBN

978-1-4244-5379-5

Electronic_ISBN

978-1-4244-5379-5

Type

conf

DOI

10.1109/ITAB.2009.5394415

Filename

5394415