Using fluidity regulation to control size distribution of lipid-coated bubbles

Lipid-coated bubbles exhibit oscillation responses that have led to them being utilized to enhance the sensitivity of ultrasound imaging by improving the contrast. Further improvements to performance enhancements by bubbles require control of their size distribution in order to promote the correspondence between the bubbles´ resonance frequency and the applied ultrasound frequency. Here we describe a fluidity regulation technique that can naturally shift the size distribution with the steps of 0.5 μm.