Title :
Integrated flow sensing for focal biochemical stimulation
Author :
Chang, Li-Yuan ; Li, Po-Ying ; Zhao, Lingyun ; Hoang, Tuan ; Meng, Ellis
Author_Institution :
Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA
Abstract :
A microfluidic platform for focal stimulation of cells and tissue allows precise biochemical control of the extracellular microenvironment. This interface consists of a polymer microchannel having a single pore through which chemicals are selectively diffused or ejected. Towards the realization of realtime feedback control of focal biochemical stimulation, integrated thermal flow sensors were used to monitor fluid release. Delivery of fluorescent dye to rat retina is also presented.
Keywords :
biosensors; chemical sensors; flow sensors; microfluidics; microsensors; temperature sensors; biochemical control; cell focal stimulation; extracellular microenvironment; flow sensing; fluorescent dye; focal biochemical stimulation; microfluidic platform; ntegrated flow sensing; polymer microchannel; rat retina; thermal flow sensors; tissue focal stimulation; Biosensors; Chemical and biological sensors; Extracellular; Feedback control; Fluid flow control; Microchannel; Microfluidics; Monitoring; Polymers; Thermal sensors; Parylene C; chemical stimulation; microfluidic delivery; thermal flow sensor;
Conference_Titel :
Nano/Micro Engineered and Molecular Systems, 2008. NEMS 2008. 3rd IEEE International Conference on
Conference_Location :
Sanya
Print_ISBN :
978-1-4244-1907-4
Electronic_ISBN :
978-1-4244-1908-1
DOI :
10.1109/NEMS.2008.4484473
