Title :
Contactless characterization of yeast cell cultivation at 7 GHz and 240 GHz
Author :
Wessel, Jan ; Schmalz, K. ; Cahill, B.P. ; Gastrock, G. ; Meliani, Chafik
Author_Institution :
IHP, Frankfurt (Oder), Germany
Abstract :
Experimental results of contactless and label-free characterization techniques of cell cultivation are presented. The two demonstrated approaches are compared at two frequencies, 7 GHz and 240 GHz in terms of sensitivity and applicability. At 7 GHz, measurements have been performed using a rat-race based characterizing system. Furthermore, the sensitivity of spectroscopy measurements at 240 GHz has been compared for two extracted parameters: phase and amplitude. The conducted experiments demonstrate that by selecting the proper characterization parameter, the presented techniques are suitable for cell cultivation monitoring in a pipe based microfluidic system with PTFE tubes. Especially, the use of higher frequencies enables a higher compactness.
Keywords :
bioMEMS; biosensors; cellular biophysics; high-frequency effects; microfluidics; microorganisms; microwave spectra; sensitivity; PTFE tubes; biosensors; contactless characterization; frequency 240 GHz; frequency 7 GHz; label-free characterization techniques; parameter extraction; pipe based microfluidic system; rat-race based characterizing system; sensitivity; spectroscopy measurements; yeast cell cultivation monitoring; Biosensors; Microfluidics; Microwave measurement; Microwave theory and techniques; Permittivity; Photoconductivity; Sugar; biosensor; label-free; microfluidic; microwave; permittivity; sub-THz;
Conference_Titel :
Biomedical Wireless Technologies, Networks, and Sensing Systems (BioWireleSS), 2013 IEEE Topical Conference on
Conference_Location :
Austin, TX
Print_ISBN :
978-1-4673-2930-9
DOI :
10.1109/BioWireleSS.2013.6613678