Real-time, High-resolution Diagnosis for Osteoarthritis in the Rat Using Common-Path Fourier-Domain Optical Coherence Tomography

Author

Sang Hun Park ; Dong Ho Shin ; Bang Young Kim ; Myoung Young Lee ; Heung Ki Baik ; Dong Heon Lee ; Jeong Hwan Seo ; Chul-Gyu Song

Author_Institution

Div. of Electron. Eng., Chonbuk Nat. Univ., Jeonju, South Korea

fYear

2013

fDate

15-17 April 2013

Firstpage

671

Lastpage

673

Abstract

The need for an inexpensive, real-time, high-resolution diagnosis for osteoarthritis (OA) is profound. After inducing OA in rats, we monitored the degradation of the articular cartilage by experimentally using in-house developed common-path Fourier-domain optical coherence tomography (CP-FDOCT). To observe the progression of OA, we injected monosodium iodoacetate (MIA) into the left knee joint. The histological images showed patterns that are similar to OCT images. These results illustrated the potential of CP-FDOCT for use in the noninvasive diagnosis of this particular grade of OA.

Keywords

biomedical optical imaging; medical image processing; optical tomography; CP-FDOCT; MIA; OA; OCT image; articular cartilage; common-path Fourier-domain optical coherence tomography; high-resolution diagnosis; histological image; knee joint; monosodium iodoacetate; noninvasive diagnosis; osteoarthritis; rat; real-time diagnosis; Coherence; Optical fibers; Optical imaging; Optical interferometry; Osteoarthritis; Tomography; articular cartilage; common path; component; Optical coherence tomography; osteoarthritis;

fLanguage

English

Publisher

ieee

Conference_Titel

Information Technology: New Generations (ITNG), 2013 Tenth International Conference on

Conference_Location

Las Vegas, NV

Print_ISBN

978-0-7695-4967-5

Type

conf

DOI

10.1109/ITNG.2013.133

Filename

6614384