DocumentCode :
3259070
Title :
A paper-based microfluidic device for multiplexed electrochemical detection of biomarkers
Author :
Chen Zhao ; Xinyu Liu
Author_Institution :
Dept. of Mech. Eng., McGill Univ., Montreal, QC, Canada
fYear :
2013
fDate :
26-30 Aug. 2013
Firstpage :
162
Lastpage :
165
Abstract :
Paper-based microfluidic devices have emerged as simple yet powerful platforms for performing low-cost analytical tests. This paper reports a microfluidic paper-based electrochemical biosensor array for multiplexed detection of disease markers. Different from existing paper-based electrochemical biosensors, our device includes an array of eight electrochemical sensors and utilizes a custom-made, handheld electrochemical reader (potentiostat) for signal readout. The biosensor array can detect several analytes in a sample solution and produce multiple measurement data for each analyte from a single run. Using the device, we demonstrate simultaneous detection of three disease-relevant metabolic biomarkers (glucose, lactate, and uric acid), with analytical performance comparable to that of the existing commercial and paper-based platforms. The paper-based biosensor array and the electrochemical reader will enable the acquisition of high-density, statistically-meaningful diagnostic information at the point of care in a rapid and cost-efficient way.
Keywords :
bioMEMS; biochemistry; biomedical equipment; biomedical measurement; biosensors; diseases; electrochemical sensors; microfluidics; microsensors; patient diagnosis; statistical analysis; sugar; disease-relevant metabolic biomarkers; glucose; handheld electrochemical reader; high-density acquisition; lactate; low-cost analytical tests; microfluidic paper-based electrochemical biosensor array; multiplexed electrochemical detection; paper-based microfluidic device; signal readout; statistically-meaningful diagnostic information; uric acid; Arrays; Biosensors; Current measurement; Electrodes; Microfluidics; Multiplexing; Sugar; bioanalysis; biosensors; electrochemical detection; paper-based microfluidics; point-oj-care diagnostics;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO), 2013 International Conference on
Conference_Location :
Suzhou
Print_ISBN :
978-1-4799-1210-0
Type :
conf
DOI :
10.1109/3M-NANO.2013.6737405
Filename :
6737405
Link To Document :
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