Lyapunov-based continuous-stirred tank bioreactor control to maximize biomass production using the haldane and monod specific growth models

Author

Kapadia, A. ; Nath, N. ; Burg, T.C. ; Dawson, D.M.

Author_Institution

Dept. of Electr. & Comput. Eng., Clemson Univ., Clemson, SC, USA

fYear

2010

fDate

June 30 2010-July 2 2010

Firstpage

6734

Lastpage

6739

Abstract

A novel robust controller is proposed for a continuous-stirred tank bioreactor that controls the culture dilution rate into the bioreactor in order to maximize a cost function representing the biomass yield. To that end, an optimal desired biomass concentration trajectory is designed based on a numerical extremum-seeking algorithm to maximize the biomass yield. A nonlinear robust controller is designed to ensure the biomass concentration tracks the desired trajectory while providing stable operation. Lyapunov-based stability analyses are used to prove semi-global tracking.

Keywords

Lyapunov methods; bioreactors; cost optimal control; nonlinear control systems; process control; renewable materials; robust control; stability; tanks (containers); Haldane growth model; Lyapunov based stability; Monod specific growth model; biomass concentration trajectory; biomass production maximization; continuous stirred tank bioreactor; cost function; dilution rate; nonlinear robust controller; numerical extremum seeking algorithm; semiglobal tracking; Adaptive control; Biological processes; Biological system modeling; Biomass; Bioreactors; Continuous production; Linear feedback control systems; Neural networks; Programmable control; Robust control;

fLanguage

English

Publisher

ieee

Conference_Titel

American Control Conference (ACC), 2010

Conference_Location

Baltimore, MD

ISSN

0743-1619

Print_ISBN

978-1-4244-7426-4

Type

conf

DOI

10.1109/ACC.2010.5531387

Filename

5531387