DocumentCode
3299374
Title
An image driven systems biology approach for neurodegenerative disease studies in the TSC-mTOR pathway
Author
Beck, Dominik ; Zhou, Xiaobo ; Pham, Tuan ; Sabatini, Bernardo ; Wong, Stephen T C
Author_Institution
Weill Med. Coll., Dept. of Radiol., Cornell Univ., Houston, TX
fYear
2009
fDate
9-10 April 2009
Firstpage
36
Lastpage
39
Abstract
In this brief paper we present an overview of the TSC-mTOR pathway and its importance in neurodegenerative disease (ND). We illustrate the influence of ND on dendritic spine morphology. Then we discuss some details of functional gene networks (FGN) and use this information to propose an image driven systems biology approach for the construction of a FGN for ND. We conclude on its importance and the prospective outcome of our study.
Keywords
complex networks; diseases; neurophysiology; TSC-mTOR pathway; dendritic spine morphology; functional gene networks; image driven systems biology; neurodegenerative disease; Biomedical imaging; Biomedical informatics; Biotechnology; Cancer; Cardiac disease; Cardiovascular diseases; Image analysis; Neodymium; Neoplasms; Systems biology;
fLanguage
English
Publisher
ieee
Conference_Titel
Life Science Systems and Applications Workshop, 2009. LiSSA 2009. IEEE/NIH
Conference_Location
Bethesda, MD
Print_ISBN
978-1-4244-4292-8
Electronic_ISBN
978-1-4244-4293-5
Type
conf
DOI
10.1109/LISSA.2009.4906703
Filename
4906703
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