Title :
Biomaterials that talk
Author :
Stayton, Patrick S. ; McDevitt, Todd ; Nelson, Kjell ; Stephans, Paige ; Long, Joanna ; Shaw, Wendy ; Gilbert, Michele ; Drobny, Gary ; Giachelli, Cecilia ; Sage, Helene ; Vernon, Robert ; Castner, Dave
Author_Institution :
Dept. for Bioeng., Washington Univ., Seattle, WA, USA
Abstract :
Summary form only given. We are working to develop a variety of biomaterials that are designed to communicate with biomolecules, cells, and tissues. Here we report the joint use of protein engineering and microfabrication approaches to generate surfaces that control cell phenotype in confined dimensions on device surfaces, and the solid-state NMR characterization of peptide and protein conformation on hydroxyapatite and hydrophobic biomaterial surfaces that interact with cell surface receptors
Keywords :
biological NMR; biological techniques; biological tissues; biomedical materials; biotechnology; cellular biophysics; molecular biophysics; proteins; biomaterials; biomolecules; cell phenotype; cell surface receptors; cells; confined dimensions; device surfaces; hydrophobic biomaterial surfaces; hydroxyapatite; microfabrication; peptide conformation; protein conformation; protein engineering; solid-state NMR characterization; tissues; Adhesives; Biomedical engineering; Geometry; Molecular biophysics; Nuclear magnetic resonance; Peptides; Probes; Protein engineering; Sequences; Solid state circuits;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.803890
