Biomaterials that talk

Author

Stayton, Patrick S. ; McDevitt, Todd ; Nelson, Kjell ; Stephans, Paige ; Long, Joanna ; Shaw, Wendy ; Gilbert, Michele ; Drobny, Gary ; Giachelli, Cecilia ; Sage, Helene ; Vernon, Robert ; Castner, Dave

Author_Institution

Dept. for Bioeng., Washington Univ., Seattle, WA, USA

Volume

2

fYear

1999

fDate

36434

Abstract

Summary form only given. We are working to develop a variety of biomaterials that are designed to communicate with biomolecules, cells, and tissues. Here we report the joint use of protein engineering and microfabrication approaches to generate surfaces that control cell phenotype in confined dimensions on device surfaces, and the solid-state NMR characterization of peptide and protein conformation on hydroxyapatite and hydrophobic biomaterial surfaces that interact with cell surface receptors

Keywords

biological NMR; biological techniques; biological tissues; biomedical materials; biotechnology; cellular biophysics; molecular biophysics; proteins; biomaterials; biomolecules; cell phenotype; cell surface receptors; cells; confined dimensions; device surfaces; hydrophobic biomaterial surfaces; hydroxyapatite; microfabrication; peptide conformation; protein conformation; protein engineering; solid-state NMR characterization; tissues; Adhesives; Biomedical engineering; Geometry; Molecular biophysics; Nuclear magnetic resonance; Peptides; Probes; Protein engineering; Sequences; Solid state circuits;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.803890

Filename

803890