Title :
Microtextured membranes promote cardiac myocyte alignment and attachment upon stretching
Author :
Deutsch, Jennifer ; Motagh, D. ; Russell, Brenda ; Desai, Tejal
Author_Institution :
Dept. of Bioeng., Illinois Univ., Chicago, IL, USA
Abstract :
Microtextured membranes have been fabricated to provide a transparent biocompatible surface with specific microarchitecture upon which cardiac myocytes exhibit enhanced cellular adhesion due to increased surface area, geometries and attachment points. The microtopography provides anisotropic or directional growth for cells and thus, can recreate tissue architecture at the cellular and subcellular level in a reproducible fashion
Keywords :
adhesion; biomechanics; biomedical materials; cardiology; cellular biophysics; membranes; texture; anisotropic growth; attachment point; cardiac myocyte alignment; cardiac myocyte attachment; cellular level; directional growth; enhanced cellular adhesion; geometry; increased surface area; microtextured membranes; microtopography; reproducible fashion; specific microarchitecture; stretching; subcellular level; tissue architecture recreation; transparent biocompatible surface; Adhesives; Biomembranes; Heart; In vitro; In vivo; Microscopy; Pediatrics; Physiology; Proteins; Visualization;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.803900
