Computer modeling of depolarization changes induced by myocardial ischemia

Author

Shenai, Mahesh ; Gramatikov, Boris ; Thakor, N.V.

Author_Institution

Johns Hopkins Univ., Baltimore, MD, USA

fYear

1998

fDate

13-16 Sep 1998

Firstpage

321

Lastpage

324

Abstract

All modes of the grid were simulated. A 2D depolarization map allowed gross visualization of normal and ischemic propagation. For some significant nodes, unipolar lead signals were obtained, to simulate unipolar recordings. Maps of ischemic depolarization showed significant difference for non-ischemic map. Time-frequency decomposition using the continuous wavelet transform was performed on the unipolar signals to determine the frequency components of the superimposed irregularity. Myocardial ischemia was shown to cause frequency domain changes during depolarization

Keywords

bioelectric potentials; diseases; electrocardiography; medical signal processing; muscle; physiological models; time-frequency analysis; wavelet transforms; 2D depolarization map; Luo-Rudy one-cell model; acidosis; anoxia; array of myocytes; computer modeling; continuous wavelet transform; depolarization changes; frequency components; frequency domain changes; gap junctions; hyperkalemia; ischemic propagation; myocardial ischemia; normal propagation; spatial domain modeling; superimposed irregularity; time-frequency decomposition; unipolar lead signals; Biological system modeling; Biology computing; Biomembranes; Continuous wavelet transforms; Frequency; Integrated circuit modeling; Ischemic pain; Myocardium; Visualization; Wavelet transforms;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology 1998

Conference_Location

Cleveland, OH

ISSN

0276-6547

Print_ISBN

0-7803-5200-9

Type

conf

DOI

10.1109/CIC.1998.731798

Filename

731798