Title :
Three-dimensional models of regionally ischemic left ventricle
Author :
Mazhari, Reza ; McCulloch, Andrew D.
Author_Institution :
Dept. of Bioeng., California Univ., San Diego, La Jolla, CA, USA
Abstract :
Regional wall mechanics were analyzed in a finite element model of the canine left ventricle that included measured three-dimensional geometry and myofiber angles, nonlinear anisotropic material properties, calcium-activated systolic myofilament tension development, and the newly reported observation of significant active stress transverse to the myofiber axis. Strain distributions in the model agreed well with experimental measurements in anesthetized dogs during left anterior descending (LAD) coronary artery occlusion
Keywords :
biomechanics; biomembrane transport; blood vessels; cardiovascular system; finite element analysis; muscle; physiological models; Ca; LAD coronary artery occlusion; active stress; anesthetized dogs; calcium-activated systolic myofilament tension development; canine left ventricle; finite element model; left anterior descending coronary artery occlusion; myofiber angles; myofiber axis; nonlinear anisotropic material properties; regional wall mechanics; regionally ischemic left ventricle; strain distributions; three-dimensional geometry; three-dimensional models; Anisotropic magnetoresistance; Arterial occlusion; Dogs; Finite element methods; Geometry; Mechanical factors; Mechanical variables measurement; Solid modeling; Strain measurement; Stress measurement;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.804367
