Title :
In vivo-activation of photodynamic hematoporphyrin-derivative (HPD) by HIFU
Author :
Spoo, J. ; Jenne, J. ; Jochle, K. ; Huber, Patrik ; Lorenz, W.J. ; Wannenmacher, M. ; Debus, Jurgen
Author_Institution :
Dept. of Radiotherapy, Heidelberg Univ., Germany
Abstract :
The object of the authors´ investigations is the in vivo-activation of photosensitizing agents by high energy ultrasound (HIFU) in order to minimize side effects and to increase penetration depth of photodynamic treatments. Animal experiments were carried out using the Dunning rat prostrate adenocarcinoma R3327-AT1 in Copenhagen rats. Macroscopic treatment response was evaluated and biologically graded. The authors were able to assess a synergistic tissue interaction of HIFU (f=1.18 MHz, I=3530 W/cm2) and hematoporphyrin-derivative
Keywords :
biological tissues; biomedical ultrasonics; organic compounds; photodynamic therapy; 1.18 MHz; Copenhagen rats; Dunning rat prostrate adenocarcinoma R3327-AT1; high energy ultrasound; in vivo-activation; macroscopic treatment response; penetration depth increase; photodynamic hematoporphyrin-derivative; side effects minimization; synergistic tissue interaction; Animals; Cancer; Hyperthermia; Medical treatment; Neoplasms; Piezoelectric transducers; Rats; Thigh; Ultrasonic imaging; Ultrasonic variables measurement;
Conference_Titel :
Ultrasonics Symposium, 1997. Proceedings., 1997 IEEE
Conference_Location :
Toronto, Ont.
Print_ISBN :
0-7803-4153-8
DOI :
10.1109/ULTSYM.1997.661824
