Title :
Notice of Retraction
Ectopic Expression of Tim-3 Induces Tumor-Specific Antitumor Immunity
Author :
Elhag, O.A.O. ; Hu Xiaojing ; Zhang Weiying ; Xiong Li ; Yuan Yongze ; Deng Lingfeng ; Liu Deli ; Liu Yingle ; Geng Hui
Author_Institution :
Hubei Key Lab. of Genetic Regul. & Integrative Biol., Central China Normal Univ., Wuhan, China
Abstract :
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
Although T-cell immunoglobulin-and mucin-domain containing molecule 3 (Tim-3) was originally identified as a negatively immunoregulator, the role of Tim-3 in regulating immune response is not fully understand. In this study, we report the finding that intratumor injection of pTim-3, a eukaryotic expression plasmid which expresses murine Tim-3 molecule, potently inhibited tumor growth and results in prolonged survival. These results gain further insight into the function of Tim-3 expressed on nonlymphoid tissues in regulating antitumor immune response.
Keywords :
biological tissues; cellular biophysics; molecular biophysics; proteins; tumours; T-cell immunoglobulin-and mucin-domain containing molecule 3; Tim-3; antitumor immune response; eukaryotic expression plasmid; immunoregulator; intratumor injection; nonlymphoid tissues; tumor-specific antitumor immunity; Biochemistry; DNA; Diseases; Immune system; Mice; Tumors;
Conference_Titel :
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location :
Wuhan
Print_ISBN :
978-1-4244-5088-6
DOI :
10.1109/icbbe.2011.5779977
