Title :
Notice of Retraction
Silent Mutation Effects on Translation Efficiency in Human Cancer Genome
Author :
Wanjun Gu ; Wei Liang
Author_Institution :
Key Lab. of Child Dev. & Learning Sci., Southeast Univ., Nanjing, China
Abstract :
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
We analyzed translation efficiency changes of 2,437 silent substitutions in human cancers. We observed selections acting on silent sites in cancer genes to increase or decrease gene translation efficiency. By comparing the selection pressures in different cancer types, we found tissue specific translation efficiency changes of cancer synonymous substitutions. We also found that substitutions in oncogenes generally tended to increase the translation efficiency. On the contrary, substitutions in tumor suppressor genes had a tendency to decrease gene expression. The results we showed here shed lights on the importance of silent mutations in cancer, which will help us understand the genetic causes of cancer.
Keywords :
cancer; genetics; genomics; medical computing; molecular biophysics; molecular configurations; tumours; cancer genes; cancer synonymous substitutions; gene expression; gene translation efficiency; human cancer; human cancer genome; oncogenes; selection pressures; silent mutation effects; tissue specific translation efficiency; tumor suppressor genes; Bioinformatics; Cancer; Databases; Encoding; Genomics; Humans; Tumors;
Conference_Titel :
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location :
Wuhan
Print_ISBN :
978-1-4244-5088-6
DOI :
10.1109/icbbe.2011.5780018
