Notice of RetractionEffects of Estradiol on Amyloid Beta and Tau Protein Positive Neurons at Hippocampal CA1 Area of Ovariectomized Dementia Rats

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

To observe the changes of amyloid beta peptide and tau protein positive of hippocampus in ovariectomized rats of Alzheimer´s disease and the effect of estrogen. The model of the AD and ovariectomized(AD+OVX) rats was established by transecting hippocampal fimbria-fornix and OVX of rats. We used Morris water maze to test the changes of cognitive function in each group. We detected the changes of amyloid beta peptide and tau protein positive of hippocampus in ovariectomized rats of Alzheimer´s disease by immunocytochemistry. The ability of learning and memory were increased significantly and the expression of amyloid beta peptide and tau protein positive of hippocampus in ovariectomized rats of Alzheimer´s disease, while amyloid beta peptide and tau protein positive of hippocampus in AD-OVX rats was decreased. EB could improve the ability of learning and memory by decreasing the level of Aβand tau protein positive of hippocampus.