• DocumentCode
    3320291
  • Title

    Analytical Solution of Gene Regulatory Networks

  • Author

    Gelenbe, Erol

  • Author_Institution
    Imperial Coll. London, London
  • fYear
    2007
  • fDate
    23-26 July 2007
  • Firstpage
    1
  • Lastpage
    6
  • Abstract
    We study gene regulatory networks that include the effect of multiple binary interactions, when various genes can activate or inhibit other genes, as well as of ternary interactions where two genes jointly affect the level of activity of a third gene. We also prove that Boolean identities for the activation state of a gene in terms of the activation level of another set of genes, can be represented, so that the overall probability of activation of any gene in the network can be computed in the presence of logical dependencies, and excitatory-inhibitory interactions between genes.
  • Keywords
    genetic engineering; genetics; probability; Boolean identities; activation probability; excitatory-inhibitory interactions; gene regulatory networks; logical dependencies; multiple binary interactions; Biological information theory; Biological system modeling; Biology computing; Cells (biology); Computer networks; Continuous time systems; Negative feedback loops; Organisms; Proteins; Time factors;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Fuzzy Systems Conference, 2007. FUZZ-IEEE 2007. IEEE International
  • Conference_Location
    London
  • ISSN
    1098-7584
  • Print_ISBN
    1-4244-1209-9
  • Electronic_ISBN
    1098-7584
  • Type

    conf

  • DOI
    10.1109/FUZZY.2007.4295674
  • Filename
    4295674