DocumentCode
3322303
Title
Notice of Retraction
Tetrandrine-Loaded Fibrous Extracellular Matrix for Cartilage Tissue Engineering
Author
Ye Zhang ; Yuan-Lu Cui ; Lei Ye ; Kang-De Yao
Author_Institution
Key Lab. of Pharmacology of Traditional Chinese Med. Formulae, Tianjin Univ. of Traditional Chinese Med., Tianjin, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
4
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
In the present study, the functions of bovine chondrocytes on tetrandrine-loaded poly (L-lactic acid) (PLLA) fibrous extracellular matrix were investigated in vitro. To mimic natural extracellular matrix architecture, a novel highly porous structure, which is a three-dimensional interconnected fibrous network has been created from PLLA in this work. These fibrous matrices were prepared from the polymer solutions by a procedure involving thermally induced gelation, solvent exchange, and freeze-drying. Tetrandrine was loaded on the scaffolds. The surface characteristics of control PLLA and tetrandrine-loaded PLLA fibrous scaffolds were examined by scanning electron microscope (SEM) and electron spectroscopy for chemical analysis (ESCA). The ESCA data suggested that the tetrandrine-loaded PLLA scaffolds were enriched with nitrogen atoms. The cell morphology, viability and histochemical analysis of bovine articular chondrocytes seeded and expanded on scaffolds were examined. These results indicated that tetrandrine loading on scaffolds could improve the chondrocytes adhesion, proliferation and function. The mesh scaffolds are suitable for cartilage reconstruction.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
In the present study, the functions of bovine chondrocytes on tetrandrine-loaded poly (L-lactic acid) (PLLA) fibrous extracellular matrix were investigated in vitro. To mimic natural extracellular matrix architecture, a novel highly porous structure, which is a three-dimensional interconnected fibrous network has been created from PLLA in this work. These fibrous matrices were prepared from the polymer solutions by a procedure involving thermally induced gelation, solvent exchange, and freeze-drying. Tetrandrine was loaded on the scaffolds. The surface characteristics of control PLLA and tetrandrine-loaded PLLA fibrous scaffolds were examined by scanning electron microscope (SEM) and electron spectroscopy for chemical analysis (ESCA). The ESCA data suggested that the tetrandrine-loaded PLLA scaffolds were enriched with nitrogen atoms. The cell morphology, viability and histochemical analysis of bovine articular chondrocytes seeded and expanded on scaffolds were examined. These results indicated that tetrandrine loading on scaffolds could improve the chondrocytes adhesion, proliferation and function. The mesh scaffolds are suitable for cartilage reconstruction.
Keywords
ESCA; adhesion; biomechanics; biomedical materials; cellular biophysics; polymer fibres; porous materials; scanning electron microscopy; tissue engineering; ESCA; SEM; bovine chondrocytes; cartilage reconstruction; cartilage tissue engineering; cell adhesion; cell function; cell morphology; cell proliferation; cell viability; chemical analysis; electron spectroscopy; freeze drying; histochemical analysis; mesh scaffolds; poly (L-lactic acid); porous structure; scanning electron microscope; solvent exchange; tetrandrine-loaded fibrous extracellular matrix; thermally induced gelation; three-dimensional interconnected fibrous network; Computer architecture; Drugs; Extracellular; Materials; Microprocessors; Scanning electron microscopy; Tissue engineering;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5780289
Filename
5780289
Link To Document