Combined role of magnetic iron oxide nanoparticles and 2.45 GHz microwave radiation on antioxidant enzymes of mice

This investigation examines the combined effect of magnetic iron oxide nanoparticles (6.5 nm) and 2.45 GHz microwave radiation. Male Swiss albino mice (7 week old) were intra-peritoneally administered different doses of magnetic iron oxide nanoparticles and were exposed to 2.45 GHz microwave radiation for 30 days. Antioxidative enzyme activity was measured in the liver and brain cells. As measured using spectroscopic methods, magnetic iron oxide nanoparticles (MION) observed to significantly increase oxidative stress in a dose dependent manner in liver and brain cells. At 0.5mg/kg and 1.0mg/kg dosage these nanoparticles did not show oxidative stress in the cells. At a high dosage of 5.0 and 10mg/kg magnetic iron oxide nanoparticles showed higher cytotoxicity than the control. A reduced GSH levels and the elevated production of malondialdehyde (MDA), was observed in the treated group animal as compare to their control counterpart. Similarly microwave irradiated group animal showed a significantly increased concentration of MDA and a decrease in GSH (glutathione) concentrations, as compared to the sham exposed group. Exposure to magnetic iron oxide and microwave radiation causes oxidative stress in mice.