ChipCE™: A silicon microsystem for migration, separation and detection of DNA

Author

Shastry, Ashutosh ; Lal, Rakesh

Author_Institution

Dept. of Electr. Eng., Indian Inst. of Technol., Bombay, India

fYear

2003

fDate

19-23 Jan. 2003

Firstpage

427

Lastpage

430

Abstract

Hand held point-of-care systems for clinical diagnostics provide an interdisciplinary frontier that has the potential to transform the way diagnosis is done today. Ability to migrate, fractionate and detect charged bio-objects in a completely portable microsystem is a vital component of these hand held point of care systems. These capabilities have been built into a free solution capillary electrophoresis (FSCE) system with on-chip electrical detection. This work reports the principles, fabricated structure, measurement approach and the results obtained for a new schema for on-chip capillary electrophoresis realized in a system that we call the ChipCE™.

Keywords

DNA; biosensors; capillarity; electrophoresis; microsensors; ChipCE™; DNA; Si microsystem; clinical diagnostics; detection; free solution capillary electrophoresis system; hand held point-of-care systems; migration; separation; Anisotropic magnetoresistance; Capacitance; DNA; Electrodes; Fabrication; Plugs; Pulse measurements; Silicon; Voltage; Wet etching;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro Electro Mechanical Systems, 2003. MEMS-03 Kyoto. IEEE The Sixteenth Annual International Conference on

ISSN

1084-6999

Print_ISBN

0-7803-7744-3

Type

conf

DOI

10.1109/MEMSYS.2003.1189777

Filename

1189777