Title :
Mining the Bioinformation of Differentially Expressed Genes in Rats Treated by Diesel Exhaust Inhalation Based on the Bioinformatics Methods
Author :
Bi, De ; Xiao, Huajun ; Zhou, Cuihong ; Zhou, Jun
Author_Institution :
Dept. of Man-Machine-Environ. Syst. Eng., Beihang Univ. (BUAA), Beijing, China
Abstract :
Objective: To analyze the differentially expressed genes expressed genes in rats that inhaled diesel exhaust (DE) for getting better understanding of the molecular characteristics caused by particle in the public environment. Methods: Got the microarray hybridization data from the Gene Expression Omnibus (GEO) database. Identified the differentially expressed genes expressed genes in DE rats and the patterns of their regulation using public bioinformatics software and database, which involved BRB-Arraytools, PANTHER and DAVID, KEGG. Results and Conclusion: These data mining findings between air and DE rats by bioinformatics methods could provide better understanding of the molecular activity change caused by DE.
Keywords :
bioinformatics; data mining; genetics; BRB-Arraytools; DAVID; KEGG; PANTHER; bioinformatics methods; bioinformation mining; diesel exhaust inhalation; differentially expressed genes; gene expression omnibus database; microarray hybridization data; molecular characteristics; public bioinformatics software; Bioinformatics; Data mining; Gene expression; Immune system; Proteins; Rats;
Conference_Titel :
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location :
Wuhan
Print_ISBN :
978-1-4244-5088-6
DOI :
10.1109/icbbe.2011.5781236
