Acid-base regulation in hemodialysis patients modeled by a simple respiratory chemostat

Author

Chiari, L. ; Avanzolini, G. ; Ursino, M.

Author_Institution

Dipt. di Elettronica Inf. e Sistemistica, Bologna Univ., Italy

Volume

5

fYear

1996

fDate

31 Oct-3 Nov 1996

Firstpage

1810

Abstract

A simplified model of carbon dioxide respiratory control is formulated and analysed. The model includes three compartments set of CO ₂ store (lungs, extracellular and intracellular fluids), a dynamic respiratory controller and a new realistic model of acid-base chemical regulation. The results obtained show that, in spite of its simplicity, the proposed model accurately reproduces steady state and transient physiological data measured during hypercapnic experiments. Moreover, it provides predictions useful to determine bicarbonate doses able to preserve the acid-base equilibrium in hemodialysis patients

Keywords

biocontrol; blood; chemical variables control; lung; patient treatment; physiological models; CO₂; CO₂ store; acid-base regulation model; bicarbonate doses; dynamic respiratory controller; extracellular fluids; hemodialysis patients; hypercapnic experiments; intracellular fluids; lungs; simple respiratory chemostat; steady state physiological data; transient physiological data; Blood; Carbon dioxide; Control systems; Extracellular; Fluid dynamics; Lungs; Mathematical model; Medical control systems; Respiratory system; Ventilation;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE

Conference_Location

Amsterdam

Print_ISBN

0-7803-3811-1

Type

conf

DOI

10.1109/IEMBS.1996.646267

Filename

646267