Chaos and second messenger signaling in excitable cells

Author

Bardakjian, B.L. ; Jeiaca, M.

Author_Institution

Inst. of Biomed. Eng., Toronto Univ., Ont., Canada

Volume

5

fYear

1996

fDate

31 Oct-3 Nov 1996

Firstpage

1913

Abstract

Routes to chaos and the domains of chaotic behavior were investigated for the cAMP signaling in excitable cells. The dynamics of cAMP signaling in the cellular molds of Dictyostelium discoideum were described by a third order nonlinear system and the different modes of cAMP oscillation were analyzed using Lyapunov exponents and bifurcation diagrams to determine the chaotic regions and their sensitivity to changes into intrinsic parameters of the model. It was concluded that cAMP receptor desensitization plays a crucial role as one of the feedback mechanisms governing the transitions between periodic and chaotic behavior of cAMP concentrations

Keywords

bioelectric phenomena; biomembrane transport; chaos; feedback; nonlinear systems; physiological models; Dictyostelium discoideum; Lyapunov exponents; bifurcation diagrams; cAMP concentrations; cAMP oscillation modes; cAMP receptor desensitization; cAMP signaling dynamics; cellular molds; chaotic behavior domains; excitable cells; feedback mechanisms; periodic behavior; second messenger signaling; third order nonlinear system; Biological system modeling; Biomembranes; Cells (biology); Chaos; Clocks; Extracellular; Feedback; Kinetic theory; Nonlinear systems; Oscillators;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE

Conference_Location

Amsterdam

Print_ISBN

0-7803-3811-1

Type

conf

DOI

10.1109/IEMBS.1996.646317

Filename

646317