FT-IR chemical imaging of biomineralized tissues using a mercury-cadmium-telluride focal-plane array detector

Author

Marcott, Curtis ; Reeder, Robert C. ; Paschalis, E.P. ; Boskey, Adele L. ; Mendelsohn, Richard

Author_Institution

Miami Valley Labs., Procter & Gamble Co., Cincinnati, OH, USA

Volume

2

fYear

1997

fDate

30 Oct-2 Nov 1997

Firstpage

693

Abstract

A 64×64 mercury-cadmium-telluride (MCT) focal-plane array detector attached to an FT-IR microscope was used to spectroscopically image 5-μm slices of human bone tissue in the fingerprint region of the infrared spectrum. The protein, carbonate, and phosphate concentrations change as function of distance from an osteon. Changes in the phosphate IR band shapes also occur, suggesting a spatial dependence to the biomineralization process

Keywords

biochemistry; biological tissues; biomedical imaging; focal planes; infrared detectors; optical arrays; orthopaedics; 5 mum; FT-IR chemical imaging; biomineralized tissues; carbonate concentration; distance from osteon; fingerprint region; medical instrumentation; mercury-cadmium-telluride focal-plane array detector; phosphate IR band shapes change; phosphate concentration; protein concentration; spatial dependence; spectroscopic imaging; Bone tissue; Chemicals; Fingerprint recognition; Humans; Infrared detectors; Infrared imaging; Microscopy; Optical imaging; Sensor arrays; Spectroscopy;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE

Conference_Location

Chicago, IL

ISSN

1094-687X

Print_ISBN

0-7803-4262-3

Type

conf

DOI

10.1109/IEMBS.1997.757724

Filename

757724