Lactate dynamics during circulatory hypoxia. Mathematical model and analysis

Author

Cabrera, Marco E. ; Saidel, Gerald M. ; Kalhan, Satish C.

Author_Institution

Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA

Volume

5

fYear

1997

fDate

1997

Firstpage

2043

Abstract

The mechanistic basis of the relationship between O₂ and lactate (LA) concentration in muscle are not fully understood. Increases in LA are frequently observed under hypoxic conditions and during high intensity exercise. However, there are other instances in which lactate can accumulate for reasons other than O₂ limitation. Our aim is to investigate, using a mathematical model and computer simulations, potential regulatory mechanisms affecting the dynamics of LA in various tissues during hypoxic conditions. Simulations of circulatory hypoxia closely predicted the pattern of change in substrates observed experimentally. Model analysis suggests that the rate of lactate production is regulated with high sensitivity through changes in ADP/ATP and NADH/NAD which are induced indirectly by a small drop in the rate of oxygen consumption due to a decrease in muscle O₂ concentration

Keywords

biochemistry; cellular biophysics; haemodynamics; haemorheology; muscle; physiological models; ADP/ATP changes; NADH/NAD changes; O₂ limitation; biochemical reactions; blood lactate; cellular metabolic processes; circulatory hypoxia; computer simulations; dynamic mass balances; human bioenergetic system; lactate dynamics; lactate production rate; mathematical model; muscle O₂ concentration; potential regulatory mechanisms; tissue perfusion; Biomedical engineering; Blood; Computational modeling; Computer simulation; Humans; Joining processes; Mathematical model; Muscles; Predictive models; Production;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE

Conference_Location

Chicago, IL

ISSN

1094-687X

Print_ISBN

0-7803-4262-3

Type

conf

DOI

10.1109/IEMBS.1997.758749

Filename

758749