Characterization of electrode/electrolyte interface for bioimpedance study

The electrochemical impedance spectroscopy (EIS) methodology has been extensively used to study the different aspects of electrochemical and biomedical practices. This paper presents the numerical simulation of impedance for electrode/electrolyte interface. The COMSOL^R Multiphysics is used to study the interface impedance. The technology for Micro Electro Mechanical system (MEMS) helps to fabricate miniature devices for the electrochemical study. In this work a MEMS based three electrode device along with Phosphate Buffered Solution (PBS) is simulated using COMSOL Multiphysics to find out the impedance of interface. PBS is used as physiological medium for most biological studies and also used to stabilize the microelectrodes under testing. The impedance obtained from COMSOL Multiphysics is processed with an equivalent circuit simulator named as ZsimpWin to find the viability of impedance of electrode/electrolyte interface.