Models of diffusion of neuromessenger, nitric oxide, in brain

Author

Wang, Tao ; Thakor, Nitish V.

Author_Institution

Dept. of Biomed. Eng., Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA

Volume

2

fYear

1995

fDate

20-23 Sep 1995

Firstpage

1509

Abstract

As a neuronal messenger molecule, nitric oxide (NO) carries out the signaling tasks by diffusing in the extracellular space surrounding the neurons. To understand diffusion process of this messenger molecule in the brain, we have developed two theoretical models that describe the concentration profiles of NO when generated from single or multiple sources. The multi-source model is developed using a bidomain concept in which multiple NO source and nonsource regions are separately considered. With these models, the diffusion times and concentration profiles of NO in the extracellular space are derived

Keywords

biodiffusion; brain models; cellular transport; neurophysiology; nitrogen compounds; NO; bidomain concept; brain; concentration profiles; diffusion models; diffusion times; extracellular space; multi-source model; multiple sources; neuromessenger; neuronal messenger molecule; neuronal tissue; nitric oxide; nonsource regions; signaling tasks; single sources; Biological system modeling; Biomedical engineering; Boundary conditions; Brain modeling; Diffusion processes; Equations; Extracellular; Filters; Neurons; Neurotransmitters;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference

Conference_Location

Montreal, Que.

Print_ISBN

0-7803-2475-7

Type

conf

DOI

10.1109/IEMBS.1995.579801

Filename

579801