Title :
Pendent chain linked delivery systems: from concept to practice
Author_Institution :
Div. of Chem. Eng., Nat. Chem. Lab., Pune, India
Abstract :
Release of active ingredients from pendent chain linked hydrogels involves penetration of the medium, hydrolysis of the pendent link and diffusion of the active ingredient. Such systems would find practical applications only when the hydrolysis takes place at pH≃7. This was achieved by (a) using poly(N-vinyl imidazole) (PNVIm) as an enzyme mimicking polymer and (b) by incorporating imidazole groups in the vicinity of the ester link to be hydrolysed. These hydrogels would also serve as pH sensitive delivery systems
Keywords :
biomedical equipment; gels; pH; patient treatment; polymers; active ingredient difusion; active ingredients release; enzyme mimicking polymer; ester link; hydrogels; hydrolysis; imidazole groups incorporation; pH sensitive delivery systems; pendent chain linked delivery systems; poly(N-vinyl imidazole); Anti-freeze; Biochemistry; Chemical engineering; Control systems; Ethanol; Laboratories; Lead; Methanol; Polymers; Testing;
Conference_Titel :
Biomedical Engineering Conference, 1996., Proceedings of the 1996 Fifteenth Southern
Conference_Location :
Dayton, OH
Print_ISBN :
0-7803-3131-1
DOI :
10.1109/SBEC.1996.493160
