Title :
VLSI-enabled DNA sequencing arrays
Author :
Singh, Rajiv Ranjan ; Manickam, Arun ; Ayazian, S. ; Hassibi, Arjang ; Shahrjerdi, Davood
Author_Institution :
Electr. & Comput. Eng. Dept., Univ. of Texas at Austin, Austin, TX, USA
Abstract :
Massively-parallel, integrated, sensitive and low-cost bio-molecular detectors are an essential part of “next generation” DNA sequencing systems. This paper discusses various design methodologies that leverage the versatility of VLSI technologies, specifically CMOS fabrication processes, to build highly integrated sequencing arrays while addressing the stringent detection and integration requirements. The goal of this paper is to discuss both the advantages and the limitations of next generation VLSI-enabled DNA sequencers.
Keywords :
CMOS integrated circuits; VLSI; biomolecular electronics; biosensors; integrated circuit design; lab-on-a-chip; CMOS fabrication process; VLSI-enabled DNA sequencing array; biomolecular detector; design methodology; next generation DNA sequencing system; next generation VLSI-enabled DNA sequencer; Arrays; Bioinformatics; Genomics; Multiplexing; Optical device fabrication; Optical sensors; Polymers;
Conference_Titel :
Circuits and Systems (MWSCAS), 2011 IEEE 54th International Midwest Symposium on
Conference_Location :
Seoul
Print_ISBN :
978-1-61284-856-3
Electronic_ISBN :
1548-3746
DOI :
10.1109/MWSCAS.2011.6026444
