Title :
Cross-interval histogram analysis of neuronal activity on multi-electrode arrays
Author :
Castellone, P. ; Rutten, W.L.C. ; Marani, E.
Author_Institution :
Inst. for Biomed. Technol., Twente Univ., Enschede, Netherlands
Abstract :
Cross-neuron-interval histogram (CNIH) analysis has been performed in order to study correlated activity and connectivity between pairs of neurons in a spontaneously active developing cultured network of rat cortical cells. Thirty-eight histograms could be analyzed using two parameters, one for the shape and one for the average number per interval bin. The histogram shape varied gradually between flat and clearly peaked around zero interval, indicating no/abundant connectivity and direct connection pathways, respectively.
Keywords :
bioelectric potentials; biomedical electrodes; correlation methods; medical signal processing; neural nets; neurophysiology; action potentials; connectivity; correlated activity; cross-interval histogram analysis; developing cultured network; extracellular activity; multielectrode arrays; neural network; neuron pairs; neuronal activity; rat cortical cells; sharply peaked histograms; spike rate; spontaneously active network; Animals; Biological neural networks; Delay; Electrodes; Histograms; In vitro; Neurons; Neurosurgery; Shape; Suspensions;
Conference_Titel :
Neural Engineering, 2003. Conference Proceedings. First International IEEE EMBS Conference on
Print_ISBN :
0-7803-7579-3
DOI :
10.1109/CNE.2003.1196820
