Title :
Evaluation of a Propofol and Remifentanil interaction model for predictive control of anesthesia induction
Author :
Ionescu, Clara M. ; De Keyser, Robin ; Struys, Michel M R F
Author_Institution :
Dept. of Electr. Energy, Syst. & Autom., Ghent Univ., Ghent, Belgium
Abstract :
This paper introduces a simplified linear interaction model between two drugs, namely Propofol and Remifentanil, which will be used in a model based predictive control algorithm for (nonlinear) automatic induction and regulation of DOA. Depth of anesthesia (DOA) is evaluated by means of the Bispectral index (BIS). The simulation tests are performed on a set of 24 virtually generated realistic patient models. The results are promising and the performance of the controller shows a high-efficiency, optimal dosage of the two drugs in order to achieve the desired BIS reference.
Keywords :
drugs; predictive control; BIS reference; DOA; Propofol; Remifentanil interaction model; anesthesia induction; bispectral index; depth of anesthesia; drug optimal dosage; linear interaction model; model based predictive control algorithm; Anesthesia; Brain modeling; Delay effects; Drugs; Electroencephalography; Mathematical model; Predictive models;
Conference_Titel :
Decision and Control and European Control Conference (CDC-ECC), 2011 50th IEEE Conference on
Conference_Location :
Orlando, FL
Print_ISBN :
978-1-61284-800-6
Electronic_ISBN :
0743-1546
DOI :
10.1109/CDC.2011.6160404
