Title :
The role of AcSDKP on inhibiting myofibroblast differentiation in rats with silicosis
Author :
Hong Xu ; Fang Yang ; Yuan Yuan ; Ying Sun ; Zhongqiu Wei ; Hua Cheng ; Shuyu Li ; Tan Cheng ; Ruimin Wang
Author_Institution :
Pathology Dept., Heibei Med. Univ., Shi Jiazhuang, China
Abstract :
Myofibroblast differentiation, characterized by α-smooth muscle actin (α-SMA) expression, is a key process in organ fibrosis. Our recent studies have shown that AcSDKP has a anti-fibrotic effect in the lung of rats with silicosis. Here we explore the underlying effect of AcSDKP on myofibroblast differentiation during the anti-fibrotic process. SiO2 powders were instilled in trachea of rat to make the silicotic model, and caused 1) increased expressions of TGF-β, 2) escalated serum response factor (SRF) expression, 3) myofibroblast marked by o-SMA being detected in siliconic nodules, and 4) collagen deposition in lung. AcSDKP (both anti fibronic and prevention treatment) can inhibit these changes induced by silica significantly. AcSDKP could inhibit collagen synthesis throuth blocking myofibroblast differentiation in the lung of rats with silicosis, which is a new mechanism of its anti-silicotic effect.
Keywords :
biochemistry; biological organs; cellular biophysics; diseases; lung; molecular biophysics; muscle; proteins; α-SMA; AcSDKP; antifibrotic effect; collagen deposition; escalated serum response factor expression; lung; myofibroblast differentiation; organ fibrosis; powders; rats; silicosis; silicotic model; smooth muscle actin expression; trachea; Diseases; Fibroblasts; Lungs; Muscles; Proteins; Rats; Silicon compounds; N-acetyl-seryl-aspartyl-lysyl-proline; a-smooth muscle actin; myoflbroblast; serum response factor; silicosis;
Conference_Titel :
Human Health and Biomedical Engineering (HHBE), 2011 International Conference on
Conference_Location :
Jilin
Print_ISBN :
978-1-61284-723-8
DOI :
10.1109/HHBE.2011.6027958