Title :
A dynamic empirical model of the human response to sodium nitroprusside during cardiac surgery
Author :
Sebald, A.V. ; Schnurer, G. ; Parti, M. ; Smith, N.T. ; Quinn, M.L.
Author_Institution :
California Univ., San Diego, La Jolla, CA, USA
Abstract :
A description is given of a partially successful attempt at using real operating room data to generate a dynamic model of the human response to sodium nitroprusside (SNP) during cardiac surgery. The principal goal of the model is to understand the problems associated with adaptive closed loop control of blood pressure during such surgeries. If successful, such a model would be valuable for simulating patients while designing controllers and would also be useful in the construction of estimation algorithms for use in adaptive controllers. The model presented dynamically relates mean arterial pressure (MAP) as a function of SNP infusion and unmeasured disturbances. It uses data (0.5-Hz sampling rate) on MAP and SNP taken over a complete cardiac surgery. Special attention is given to modeling the noise characteristics of the MAP signal.<>
Keywords :
cardiology; haemodynamics; physiological models; surgery; 0.5 Hz; Na nitroprusside; blood pressure; cardiac surgery; closed loop control; dynamic empirical model; estimation algorithms; human response; mean arterial pressure; noise characteristics; noise characteristics modelling;
Conference_Titel :
Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE
Conference_Location :
New Orleans, LA, USA
Print_ISBN :
0-7803-0785-2
DOI :
10.1109/IEMBS.1988.94637
