Myocardial protective effect of 3-aminobenzamide through inhibition of poly (ADP-ribose) polymerase activation in diabetic rats

To investigate myocardial protective effect of 3-aminobenzamide (3-AB) in STZ-induced diabetic rats and its mechanism. In the 12th weekend plasma glucose, heart function, the levels of myocardial 8-OHdG and 3-NT and the expression changes of PARP1 at the protein level are detected. The study shows that after 12 weeks of STZ treatment the plasma glucose concentration, 8-OHdG and 3-NT level and the protein expression of PARP1 of diabetic rats were significantly (P<;0.01) higher than the control group. Diabetic rats treated with STZ for 12 weeks show a significant cardiac dysfunction. Compared with the diabetes model group, blood glucose and 3-NT levels decreased, cardiac function improved and PARP1 protein downregulated (P<;0.01) in the diabetic rats of 3-AB treatment. PARP inhibitor 3-AB can protect myocardium through reducing blood glucose and the stress response of nitrification to some extent, downregulating PARP1 expression and improving heart function in diabetic rats.