Optical coherence imaging of tumor spheroids

Summary form only given. Recent development of optical coherence imaging (OCI) based on adaptive holographic film has shown promising applications in biological imaging. Previous systems had used reflective geometry in detection and performed light collection from different depths in the sample by changing the delay of reference arm. However, the reflective geometry is not suitable for a sample with very weak reflection and with many static scattering centers. To make measurements of translucent samples such as tumor spheroids, we develop an optical coherence imaging system based on a modified Mach-Zehnder interferometer and photorefractive quantum well device with transmission through the sample. Using this system we have achieved coherent images through translucent tumor spheroids.